What’s In Your Health Supplement? A Guide to MakeWell’s OPC Plus

This article is intended for customers from all countries other than Germany*

Lyme disease can be a debilitating and unrelenting condition. When caught early, it can be treated with antibiotics. However, the bacteria that causes the chronic illness can stick around in the joints, tissues and lymph nodes, waiting for its chance to wreak havoc all over again. When managing a Lyme disease infection, it’s important to get treatment promptly, lead a healthy lifestyle when it comes to diet and exercise, and add in some helpful supplementation.

MakeWell’s OPC Plus supplement is a great addition to a Lyme disease recovery treatment plan. It acts as a supportive treatment of Lyme disease when used in conjunction with other methods of recovery.  This nutritional supplement for Lyme disease uses four powerful plant-based ingredients that can be beneficial with issues such as oxidative stress and inflammation.


Bromelain is most commonly found in pineapples. The enzymes that make up bromelain work to digest proteins within the body. It has been used and/or studied for different applications in the past, such as:

  • Topical burns
  • Inflammation
  • Swelling
  • Heart disease
  • Stroke
  • Asthma
  • Chronic sinusitis

Bromelain also has analgesic and anticoagulant properties that can help battle blood clot formation and chronic pain. It is not a medicine, but it can be an additional support.


MakeWell - bromelain pineapple
Image by Pineapple Supply Co. on Unsplash: Bromelain (most commonly found in pineapples) has a plethora of health benefits when added to a nutritional supplement for Lyme disease.

Grapeseed Extract

Grapeseed extract is derived from the seeds of grapes. Although many grapes now come seedless at the request of consumers, the seeds are a great addition to MakeWell’s OPC Plus supplement because of their anti-inflammatory and antioxidative properties.

There are two specific compounds in grapeseeds that make them a holy grail when it comes to supplementation:


Polyphenols are plant metabolites that give fruits and vegetables their health benefits. They are micronutrients that have anti-inflammatory and antioxidative properties, and can aid in digestion, weight management, the cardiovascular system and brain health.

Oligomeric proanthocyanidins (OPC)

OPC is a subgroup of flavanols. It has been used to aid in the treatment of ailments including diabetes and joint swelling, and also can have a direct and positive impact on vein function and blood flow.

Together, these elements can improve the symptoms of Lyme disease and help supplement ongoing treatment plans.

Curcuma Extract

Curcuma extract is derived from the turmeric plant. Turmeric has been used medicinally for centuries to help with inflammation, cognitive dysfunction, heart disease and arthritis. The curcuma extract is the part of the turmeric plant that holds all these medicinal properties and acts as both an anti-inflammatory and antioxidant. It contains high levels of curcuminoids and is able to alter NF-kB, a factor involved in inflammation and gene regulation throughout the body.

In the case of Lyme disease, inflammation can be a huge problem; the brain, heart, joints and muscles can all be rendered dysfunctional because of inflammation. Curcuma extract can help to combat this. It isn’t a cure-all for the debilitating symptoms of Lyme disease, but studies have shown positive outcomes regarding inflammation.

Knotweed Extract

Used popularly in Chinese medicine, knotweed extract has a centuries-old reputation for assisting indifferent areas of health care. For example it is a plant rich in resveratrol, making it perfect for a supplement that helps fight Lyme disease.

Knotweed helps to as an addition in chronic illness because of its high levels of resveratrol. Resveratrol is a powerful polyphenol that has been used most notably in the cosmetic industry as a way to help halt the signs of ageing. When it comes to chronic illnesses such as Lyme disease, resveratrol contains properties that help neutralise oxidative stress in the body, minimising cell damage.


MakeWell - Japanese Knotweed
Image by HOerwin56 from Pixabay: Knotweed gets its beneficial properties from a high resveratrol content.. Resveratrol is also commonly found in red grapes

MakeWell’s OPC Plus combination benefits

The combination of the aforementioned ingredients is what gives MakeWell’s OPC plus supplement its potency and efficacy in aiding an existing treatment plan for Lyme disease. Like all other

MakeWell supplements, OPC Plus is lab-tested and free from any pesticides, heavy metals or residues that could lower its ability to help treat chronic disease. All ingredients mentioned above are also plant-based and pure quality.

When it comes to battling Lyme disease, treatment can be an arduous journey. There is help to be found, though. For more information on MakeWell’s OPC Plus and how it can help you in your battle with Lyme disease, contact us and we’ll get back to you with more information as soon as possible.

Featured image by Volodymyr Hryshckenko on Unsplash


References and further literature

Ghanim, Husam, et al. "An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol." The Journal of Clinical Endocrinology & Metabolism 95.9 (2010): E1-E8.

Itokawa, Hideji, et al. "Recent advances in the investigation of curcuminoids." Chinese Medicine 3.1 (2008): 11.

Rao, M. N. A. "Nitric oxide scavenging by curcuminoids." Journal of pharmacy and Pharmacology 49.1 (1997): 105-107.

Saptarini, Nyi M., Driyanti Rahayu, and Irma E. Herawati. "Antioxidant activity of crude bromelain of pineapple (Ananas comosus (L.) Merr) crown from Subang district, Indonesia." Journal of Pharmacy & Bioallied Sciences 11.Suppl 4 (2019): S551.

Seligman, Bert. "Bromelain: an anti-inflammatory agent." Angiology 13.11 (1962): 508-510.

Yilmaz, Yusuf, and Romeo T. Toledo. "Health aspects of functional grape seed constituents." Trends in food science & technology 15.9 (2004): 422-433.