What Is NADH And How Can Supplementation Help Those With Chronic Illness?

This article is intended for customers from all countries other than Germany*

Energy levels are important for those suffering from chronic illness. They can mean the difference between getting through the day and struggling to battle debilitating symptoms. For chronic illness sufferers, finding the energy to do even the most minute tasks can be difficult, but it doesn’t always have to be an uphill battle.

Ensuring that you have enough energy to deal with chronic illness might not always be doable in terms of diet and exercise alone; in a lot of cases, supplementation may be required for the body to function at its most optimal level. For those who do suffer from low energy caused by a chronic illness, a supplement containing NADH is a good addition to their daily routine. So what is NADH and what is its function?


What is NADH?

Nicotinamide adenine dinucleotide plus hydrogen (NADH) is a naturally occurring chemical that plays an important role in different bodily functions, such as the creation of energy that occurs on a cellular level in our mitochondria. NADH and its redox pair, NAD+, have further been described to be involved in numerous other important processes and functions, such as having a possible effect on our immune system, on cellular repair and mitochondrial fitness. 

All of these processes play an important role in overall energy levels and well being throughout the day. For a person to have the energy to run for the bus or even make dinner after a long day at the office, these energy processes must be working simultaneously at their best levels.


What is NADH used for?

Every cell in the human body needs to use energy to get its specific job done. Considering there are over 100 trillion cells in the body, that’s a lot of energy expenditure needed just to keep things running smoothly. NADH is used by every single cell, and in the processes mentioned above, to help keep everything moving.

When production of NADH is inhibited, it can throw the entire system off as the body becomes exhausted on a truly cellular level.


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Image by Braden Collum on Unsplash: NADH is required to give the body a quick burst of energy when needed.

Symptoms of NADH deficiency

For those who suffer from a lack of NADH in their system, certain chronic ailments can arise, because without the proper energy in the cells, the cells will perish. Some studies have suggested that when the cells in the body are tired, it can lead to chronic issues such as fibromyalgia, the exacerbation of Lyme disease, and general feelings of fatigue.

It has also been said that NADH deficiency can play a huge role in lowered function of the immune system, cognitive decline, mental illnesses including depression and anxiety, and unstable moods. For those with chronic illnesses, a NADH deficiency can wreak havoc on the body’s systems because they are already functioning at a lower level. Since it can affect the way the immune system works (and many with chronic illnesses depend on proper immune function to deal with symptoms), NADH deficiency can lead to further exacerbation of symptoms and longer recovery times.


What is the difference between NAD+ and NADH?

There is some confusion regarding the difference between NADH and NAD+. While they are both critical in the production of energy, NADH typically has a high energy profile and contributes to shorter bursts of high energy, while NAD+ tends to create energy that can last for longer periods of time. NAD+ can also have positive effects on slowing the ageing process, DNA repair, cellular stress response, and lowering the risk of chronic disease.

Recent studies have shown that when giving people NAD precursors such as NMN (nicotinamide) and NR (nicotinamide riboside), the prevention of certain metabolic diseases was not far behind. More innovative supplements provide the NAD+ molecule as a whole. To put it simply, both NADH and NAD+ are required for energy production, but they can’t do the same job. The two need to work in conjunction at the optimal ratio for energy processes to work as they should.


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Image by Malin K. on Unsplash: Some studies have suggested that NAD+ can help slow the ageing process.

What is the best NAD supplement?

For those who suffer from an imbalance in their energy metabolism, NADH and/or NAD+, supplementation is available. Make Well offers a specific supplement that was designed to target energy levels with a specific combination of helpful ingredients, including NADH. Energy Plus is fructose-, lactose- and gluten-free and gives those suffering from chronic illness, including Lyme disease, a fighting chance at a cellular level. Let’s take a look at some of the ingredients of the Energy Plus supplement:


Live lactic acid bacteria

Low energy levels can have a number of different causes. An imbalance in our microbiome - the microbial community our gut gives host to - is once such cause. Our gut can influence our susceptibility to several problematic symptoms such as tiredness, mood swings, immune deficiencies, and many others. This is why supporting the gut flora with live lactic acid bacteria is a helpful addition to an energy support supplement.

Phosphatidylcholine and Phosphatidylserine

Both phosphatidylcholine and phosphatidylserine play important roles in our cellular health. They are part of our cell’s and mitochondrial membranes and contribute to their integrity. The phosphatidylcholine used in our supplement is vegan, soy based and of the highest purity available. 


L-Carnitine is known for its role as a fatty acid shuttle. Long chain fatty acids can be broken down in our mitochondria and put to use in energy production by a process called ß-oxidation. The transfer that occurs over the mitochondrial membrane is enabled by a so-called carnitine shuttle, whereby fatty acids are bound to carnitine and transported together.

Coenzyme Q10

Just like NADH and NAD+, coenzyme Q10 can exist in two chemical forms, namely ubiquinone and ubiquinol. The coenzyme Q10 is an electron carrier, meaning it contributes to the electron transport chain that works along the mitochondrial membrane in order to produce ATP - the source of our cellular energy.

Vitamin C

Vitamin C is probably one of the most well-known vitamins associated with maintaining a healthy immune system. However, vitamin C, or ascorbic acid, has many more far reaching functions for our body. One of those is its ability to reduce feelings of tiredness and fatigue, making it a great addition to our Energy plus supplement.


Featured image by Stacey Gabrielle Koenitz Rozells on Unsplash