What Is S-Acetyl-Glutathione And How Can It Help In The Battle Of Chronic Disease?

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The body is constantly battling the build-up of free radicals. Free radicals are molecules that contain oxygen (ROS) or nitrogen (NOS) and occur when their outer shell lacks an electron, essentially creating an unstable version of themselves. When this occurs, oxidative stress can take over, causing damage to the body. Not all levels of free radicals are damaging, and some can even be good – but there needs to be a constant balance between free radicals and antioxidants.

Antioxidants are designed to help combat the overabundance of free radicals that could cause oxidative stress. With the right amount of both antioxidants and free radicals, the body will be in harmony, but even the slightest imbalance can lead to serious health issues. Glutathione is an important antioxidant that aids in keeping up that stability. So what is S-Acetyl-Glutathione, exactly?


What is S-Acetyl-Glutathione?

Glutathione is a naturally occurring tripeptide produced by the liver. Amongst other purposes, it acts as an antioxidant to help restore healthy levels of free radicals.

Glutathione exists in two distinct chemical forms. The preliminary form for oral application has been plain (reduced) glutathione, which can have many limitations, such as bioavailability. S-Acetyl-Glutathione (SAG) has a small chemical change: an additional acetyl group protecting the delicate part of the plain reduced glutathione and increasing its stability and bioavailability. It can therefore be considered the superior form of glutathione for oral application.

So does glutathione help with inflammation? And does glutathione fight infection? S-Acetyl-Glutathione has been used as a supplement to help in many clinical fields, including:

  • Neurodegenerative diseases
  • Gastrointestinal issues
  • Cardiovascular system
  • Chronic fatigue syndrome & energy metabolism
  • Mental health
  • Inflammation
  • Immune system

Glutathione has also been shown to aid in the slowing of the ageing process. One study found that the use of a precursor form of glutathione could actually increase longevity and healthy ageing in mice.


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Image by Public Domain Pictures on Pixabay: Glutathione supplements have been difficult to absorb, but new formulas are changing that.

What is the function of glutathione in the body?

Glutathione is found in high amounts in most cells. It isn’t just a good antioxidant; it has also been shown to play an integral role in the proper functioning of many systems. Glutathione has a direct effect on how vitamin C and E stores regenerate within the body, as well as the chemical neutralisation of oxygen, hydroxyl radicals and superoxide radicals.

It also plays an important role in proper immune function, the energy metabolism, and liver phase II detoxification, which is crucial for the elimination of toxins from our bodies.

What does a glutathione deficiency look like?

A glutathione deficiency or disruption can have an effect on oxidative stress and cause symptoms like fatigue or exhaustion. Since oxidative stress can lead to many health problems, knowing the signs and symptoms of low levels of glutathione can make a big difference in battling chronic health issues.

Symptoms often associated with low levels of glutathione can range from mild to severe, and can include:

  • Chronic fatigue
  • Pain and inflammation
  • Cognitive dysfunction such as brain fog and poor sleep
  • Lowered immunity
  • Haemolytic anaemia (when red blood cells are broken down too quickly to be replaced – comes with its own symptoms: pale skin, lightheadedness, shortness of breath)
  • Neurological issues and illnesses which may include seizures and ataxia

What does S-Acetyl-Glutathione supplementation do?

Supplementing with glutathione has been difficult up until recently, with most of its availability coming only in the form of expensive intravenous therapy for more serious cases, or in pills that cannot make it through the digestive system properly. But it is now available in capsule form, so anyone with even the mildest deficiency can balance their levels and improve their overall health.

When a person supplements their levels of glutathione, they can decrease the overall amount of free radicals found in their body, which leads to a decreased risk of developing oxidative stress. It’s recommended that glutathione be restored through supplementation after you fall ill, as well as when you become older, as it depletes on its own during illness and the aging process.

So what is the best glutathione supplement? One supplement that can improve the body’s natural levels of glutathione is MakeWell’s SAG plus 300, containing highly dosed S-Acetyl-Glutathione in premium quality.


MakeWell - brain health
Image by Hainguyenrp on Unsplash: What is acetyl glutathione good for? Levels of glutathione have a direct impact on brain health.

How can S-acetyl glutathione help those with chronic illness?

People with chronic illness can be more at risk of developing a build-up of free radicals and experiencing oxidative stress and lessened organ function. Glutathione deficiency has also been considered a risk factor for developing chronic illness. Some research has suggested that people with chronic illness could restore balance to their body with the supplementation of glutathione, thus reversing some debilitating symptoms of their chronic disease.

The liver creates its own glutathione, but most important for cellular health  is the ratio between the two chemical states (reduced & oxidised). Supplementation with SAG is a great way to help boost intracellular levels of reduced glutathione to restore this delicate balance, without affecting the endogenous glutathione synthesis.

Featured image by Kinga Cichewicz on Unsplash