What’s In Your Health Supplement? A Guide To MakeWell’s SAG Plus

MakeWell - SAG plus 300

This article is intended for customers from all countries other than Germany*

Oxidative stress and the presence of larger amounts of potentially harmful reactive species play a role in ageing as well as numerous other health conditions. Antioxidants like glutathione can aid the neutralisation of reactive species and therefore play an important role in health and disease. MakeWell’s latest addition to their product range, the product  SAG Plus 300, is a powerful collection of ingredients that can help lessen the risk for oxidative stress by providing an innovative formula for oral glutathione delivery with increased bioavailability.

What is oxidative stress?

Oxidative stress can happen to anyone at any age, but the older a person gets, the more susceptible they may become to the weakened function of tissues and organs. One theory has suggested that oxidative stress is caused by an increase in reactive oxygen and nitrogen species and the build-up of damage to lipids, DNA and proteins over time.

Some natural supports for oxidative stress can help battle the chronic illness that sometimes develops because of it. Eating a healthy diet with essential nutrients and vitamins, avoiding smoking and excess alcohol consumption, reducing stress, and exercising are all great ways to help avoid excessive oxidative stress that can lead to lasting damage.

MakeWell’s SAG Plus 300 supplement

Although a nutritional supplement for oxidative stress isn’t going to stop the ageing process, it can help keep cells healthy and be a great addition to a healthy life. Glutathione, often referred to as ‘the master antioxidant’, has been known for its numerous health applications for a long time. However, many obstacles with oral delivery, such as low bioavailability, have lowered its success profoundly.

MakeWell’s SAG Plus 300 supplement includes a variety of ingredients selected to encourage cellular health, including a chemically altered (acetylated) form of glutathione, which is superior in stability and bioavailability compared to other glutathione supplements.

Below is a breakdown of MakeWell’s SAG Plus supplement ingredients.

SAG (S-Acetyl-Glutathione)

Glutathione is a naturally occurring antioxidant that can be found in different organisms. It is a tripeptide of three amino acids and is created in the liver. The role of glutathione within the body is to encourage optimal cellular health – for example, by reducing overall levels of oxidative stress. It also plays a role in proper immune function, detoxification, recycling of other antioxidative substances, and many more processes.

Most important is the intracellular ratio of glutathione’s two chemical states, namely reduced and oxidised. Reduced glutathione levels exceed oxidised glutathione levels by far, which is a delicate homeostasis. Intracellular reduced glutathione is known to decrease with the ageing process, but it can also be negatively affected by poor diet, chronic stress and other circumstances.

In its pure (reduced) form, the amino acid combination can be hard to absorb in the body, thus making it harder to increase levels. This can be due to different reasons, such as the stability of the molecule itself, but also because the reduced form can be prone to oxidation prior to use.

MakeWell’s SAG Plus 300 has added acetyl chemical residue to protect the glutathione’s thiol groups so that it has better cellular uptake, meaning more can be absorbed.  Additionally, a longer half-life in human plasma has been described, and the glutathione molecule is protected from preliminary oxidation and does not inhibit our body’s own ability to keep synthesising glutathione internally. SAG is a superior form of glutathione, which can be an excellent alternative for expensive IV treatments to administer at home in between infusions.


MakeWell - coconut oil
Image by Tijana Drndarski on Unsplash: Coconut oil is a MCT oil that has gained increased popularity in recent years for its proposed health benefits.

Medium Chain Triglycerides (MCT oils)

MCT oils are fatty acids of a medium chain length, which can be absorbed into the body quickly. When consumed, they go directly to the liver to be used for energy. In recent years, they have been hailed as a great aid in fat loss because of their ability to be absorbed through the small intestine without much help from lipase or bile acids, and their lower content of calories compared to long-chain fatty acids.

Studies have also shown that MCT oils may aid in the prevention and treatment of Candida albicans infections. Other studies have suggested that the ingestion of MCT oils can help in balancing cholesterol levels, lowering blood sugar levels, and helping to treat liver disease and gastrointestinal issues such as diarrhoea.


Carnitine is a compound that aids in energy metabolism function. It helps transport long-chain fatty acids inside the mitochondria to be oxidised and used for energy and degradation. Acetylated L-carnitine in particular has been researched in animal models for its properties to cross the blood-brain barrier effectively.


The trace element selenium is not naturally occurring, but it is an important nutrient when it comes to overall levels of health. Since it is a trace element, only a small amount of selenium is required for it to do its job. It acts as an antioxidant and performs other different mechanisms of action in the body.

This nutrient is found mostly in nuts, organ meats and mushrooms; however, it can be difficult to get enough selenium through diet. Selenium can be better absorbed when it comes in the form of organic compounds. Ingesting too much selenium, however, can lead to toxic and harmful side effects, so it’s important to avoid taking too many supplements containing selenium at the same time.

MakeWell’s SAG Plus 300 supplement contains an organic form of selenium with high bioavailability.


MakeWell - brazil nuts
Image by Gadini on Pixabay: Nuts can be a great source of selenium.

Vitamin B12

Otherwise known as methylcobalamin, vitamin B12 is a vital component to overall health. The essential nutrient is a cofactor to enzymes methionine synthase and methylmalonyl CoA mutase, which have a direct effect on methylation reaction within the body, as well as folate metabolism.

According to some studies, B12 can help restore normal homocysteine levels and contribute to the proper function of the nervous system. It also has a positive impact on energy metabolism. Deficiencies in B12 are quite common, especially among people who follow a vegan diet, so supplementation is often necessary.

Featured image by Sharon McCutcheon on Unsplash


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