Make Well - fatigue

In today’s fast-paced world, it’s easy to get a little run down every now and again. Most, if not all people feel tired at some point during the day, whether it’s right when they wake up, after a full day of work, or when they’re hitting the pillow after the day is done. But is feeling tired on a daily basis the same thing as fatigue?

The short answer is no. Tiredness is associated with daily activities and happens to everyone. Fatigue, on the other hand, is a chronic ailment that causes people to suffer an overall full-body feeling of exhaustion that doesn’t ease up, no matter how rested one may be.

It’s hard to pinpoint the direct cause of chronic or generalised fatigue; it can stem from many different problems, and the source is specific to each person who suffers from it. However, today we’ll be taking a look at some of the top causes of fatigue and how to treat them.

What are the causes of fatigue?

As mentioned above, there are many reasons why a person could suffer through chronic fatigue in their daily life. In fact, there are five main causes of fatigue:

  • Sleep disorders
  • Medical conditions
  • Diet
  • Mental health conditions
  • Dehydration

Each different source can have a serious impact on quality of life, and each has different options for treatment.

Sleep disorders

There are many sleep disorders or other sleep disruptions that can cause fatigue. They include:

  • Insomnia
  • Sleep apnoea
  • Narcolepsy
  • Restless leg syndrome
  • Shift work
  • Jet lag

For people who suffer from a sleep disorder such as sleep apnoea or insomnia, getting enough restful sleep can be a feat in and of itself. This is due to the brain’s inability to repair itself during the night caused by a lack of proper REM cycling. When the brain is not getting the rest it needs, it cannot restore itself, thus resulting in fatigue that can affect both the mind and body.

Treating a sleeping disorder can be difficult, but it can be done. If insomnia is the issue, creating a nightly routine and using a natural sleep aid such as melatonin may work wonders.


Make Well - causes of fatigue
Image by Anthony Tran on Unsplash: If you’re asking yourself “Why am I so tired all the time?”, you may suffer from insomnia, a sleep disorder that can lead to fatigue.

Medical conditions

Certain medical conditions can also cause fatigue. They include:

  • Cancer
  • Fibromyalgia
  • Lupus
  • Rheumatoid arthritis
  • Anaemia
  • Addison’s disease
  • Hyper- or hypothyroidism

These conditions cause fatigue for different reasons. In the case of fibromyalgia, a condition that causes widespread pain throughout the body, it’s theorised that fatigue is the body’s way of handling or dealing with being in a constant state of physical turmoil. When the nerve signals in the body are overreacting to pain, it can lead to lethargy.

Anaemia causes fatigue for an entirely different reason. Anaemia affects the body’s ability to produce haemoglobin (reliant on having enough iron in the system). Haemoglobin is a protein that is responsible for carrying oxygen throughout the body. When the body doesn’t have enough haemoglobin, it can lead to fatigue on a cellular level.


The body needs a diet full of wholefoods, fruits and vegetables for it to run at its best. When the diet is overly processed or lacking in essential vitamins and nutrients, it can lead to deficiencies, which can in turn cause fatigue.

Specific nutritional deficiencies that can lead to chronic fatigue include:

  • Iron
  • Magnesium
  • Potassium
  • Vitamin B12
  • Folic Acid

As mentioned above, a lack of iron leads to anaemia. Similarly for these other minerals and vitamins, when the body is deficient, fatigue doesn’t come far behind.


Make Well - wholefoods
Image by Magalie De Preux on Unsplash: How can I boost my energy naturally? Turn to wholefoods. 

Mental health conditions

Some conditions that can lead to fatigue aren’t overly reliant on the amount of sleep one gets, or even how well they are taking care of their body. In the case of fatigue, mental health conditions can cause someone to feel overly exhausted on a day-to-day basis.

Mental health conditions that often lead to chronic fatigue include:

  • Stress
  • Depression
  • Anxiety
  • Grief
  • Eating disorders
  • Drug and alcohol abuse

A person can experience fatigue due to the mental and physical exhaustion of dealing with a mental illness. Mental health conditions can lead to poor diet, insomnia, lack of restful sleep, and other health issues – all things that prolong and worsen fatigue.


Not drinking enough water can be detrimental to more than your overall wellbeing. Being dehydrated can lead to chronic fatigue because when there isn’t enough fluid in the body, the heart has to pick up the extra slack to push the oxygen and nutrients where they need to go. This extra stress on the heart and body leads to a level of fatigue that can last for days on end.


How to treat fatigue

The first step in treating fatigue is finding the source. Since the cause of the ailment is unique to each person, it’s important to get to the bottom of your symptoms to determine whether a serious medical condition such as cancer could be causing the fatigue.

Treatment for fatigue will range significantly depending on the cause. For those who suffer from sleep disorders, paying a visit to a sleep clinic can be a great option. In the case of dehydration, increasing water intake could be a simple fix, but in the case of a mental health condition such as depression, the road to recovery may be longer and more complicated.

It’s best to see a mental health professional, but in general, you can begin a holistic approach by getting the proper amount of exercise, eating a diet rich in nutrient-dense foods, and practising mindfulness and meditation – all of which been proven to lead to a lessened level of anxiety and depression in individuals who kept up a good routine regularly.

For those who suffer from a lack of nutrients, taking a multivitamin can be a great first step in ensuring that the body is getting what it needs, when it needs it. Make Well’s Energy Plus and MITO Plus are both great options when deciding what supplementation is right for you. The Make Well team is also working towards another fatigue-specific product to help in the fight against chronic fatigue.

Featured image by Yuris Alhumaydy on Unsplash

Make Well - fasting

People who suffer from Lyme disease often have a hard time battling chronic symptoms, such as:

  • joint aches
  • fatigue
  • issues with regular and restful sleep
  • inflammation in the body
  • cognitive disfunction, including memory loss and trouble concentrating.

These symptoms often take a while to develop after the onset of the infection, but they are tough to get rid of, since the bacteria that causes Lyme disease can often go dormant within the body for years.

The only way to treat Lyme disease is through a course of antibiotics, and even then it can be difficult to rid the body of lasting symptoms. When it comes to further treatment, symptoms are primarily focused on to help improve quality of life for those with late-stage or chronic Lyme disease. Some treatments include medications for specific ailments, dietary and lifestyle changes, and over-the-counter pain relief medications. But does fasting benefit Lyme patients as a type of treatment? Let’s investigate.

What is fasting, and can fasting be used to treat Lyme symptoms?

Fasting is denying the body of food for a certain period of time. Some fasting is done for days on end, while other types, including intermittent fasting, involve eating food only during a short window each day.

People adopt fasting lifestyles for many different reasons. According to some studies, fasting can:

  • lower insulin resistance and control blood sugar
  • fight inflammation
  • boost cognitive function
  • increase hormone secretion, which can lead to healthier muscles
  • increase the efficacy of other medications.

As people with Lyme disease often suffer from an onslaught of different symptoms, including

decreased cognitive function, inflammation and muscle and joint aches, fasting is said to have positive effects when used in the treatment of long-term Lyme disease symptoms. There has also been a direct correlation of fasting to damage repair and the reduction of oxidative stress throughout the body – both of which play a huge role in advancing chronic disease and the symptoms that often go hand in hand with it.


Image by Laurynas Mereckas on Unsplash: Intermittent fasting and Lyme disease: Can you do it while taking medication? Only with a doctor's guidance.

Intermittent fasting and Lyme disease

As mentioned above, there are different types of fasting. Intermittent fasting is more lenient in that a person can eat, but only for a set number of hours each day. Although it is often hailed as a kind of ‘miracle diet’ for those looking to shed a few pounds, fasting has also been observed to have a positive effect on chronic disease symptoms that often ail Lyme disease patients.

There are some downsides to intermittent fasting, though. Those who partake are told to eat whatever they want as long as they stay within the allotted time window to keep true to the fast; this can often lead to overeating unhealthy foods, which can exacerbate symptoms of Lyme disease such as inflammation. When the diet isn’t in check, inflammation can wreak havoc on a body with a chronic illness.

Fasting has the potential to be dangerous as well, so it’s important to be mindful of personal health considerations when deciding whether or not it is right for you. Speaking with your doctor about how many calories you can limit your diet to per day, as well as taking daily medications that are required to be taken with food into account, will help you get on the right path when it comes to fasting.

Is fasting safe if you have Lyme disease?

During a fast, many changes take place in the body. The food you eat is what gives you energy, and the energy is released throughout the body from the liver and muscles in the form of glucose. When you fast, this process changes.

When deprived of glucose, our body uses alternative pathways, such as gluconeogenesis, or produces ketone bodies from fatty acids, to sustain energy supply for vital organs like the brain. This state can contribute to reduction of tiredness and inflammation.

The digestive system also gets a break when you deny the body food for a certain amount of time, and since that energy is no longer being used for digestion, it allows for the immune system to lessen its workload. This can make the immune system stronger to fight off further infection.

Fasting has also been a method used in the detoxification and cleansing of the body. It gives the body the chance to rid itself of anything it doesn’t need. When it comes to Lyme disease sufferers, a build-up of toxins can hinder recovery – another reason fasting may be beneficial for Lyme patients.


Make Well - pain
Image by Afif Kusuma on Unsplash: Chronic Lyme disease can cause widespread inflammation and pain throughout the body in people of any age. But is fasting beneficial to Lyme patients?

Is fasting beneficial to Lyme patients?

Although the benefits of fasting and intermittent fasting depend highly on a case-by-case basis, fasting does offer some help in the way of battling chronic Lyme disease. Giving the body a break from digestion can allow it to repair some damage done by the bacteria that causes Lyme disease, and also help curb inflammation caused by eating certain foods (as long as the diet is full of wholefoods, fruits and vegetables while in the eating phase of the fast).

Fasting is generally a safe method of encouraging healthy recovery from chronic Lyme disease symptoms, but should be approached in a knowledgeable and controlled way. The best way to start a fast to help treat chronic symptoms of Lyme disease is to speak with your doctor and decide on a course of action that will be beneficial to you.

Featured image by Oladimeji Ajegbile on Unsplash

Make Well - bacteria

Lyme disease is a tick-borne illness caused by the transfer of Borrelia bacteria from an infected tick to its host. If left untreated, Lyme often comes with a wide range of debilitating effects, including flu-like symptoms, arthritis and cognitive disfunction. The treatment for Lyme disease is an antibiotics course, but if the disease has progressed past early-stage Lyme disease, treatment can become near impossible as the bacteria sticks around, causing chronic Lyme disease.

When a person is diagnosed with Lyme disease, the condition is often found to occur simultaneously with a wide array of other infections. These are referred to as Lyme disease co-infections. Additional side effects can further occur, such as candidiasis. Let’s take a look at exactly what candidiasis is, and why candidiasis is common in Lyme disease patients.


Image by Pexels on Pixabay: Is candidiasis common in Lyme disease patients? Let’s find out.

Signs and symptoms of candidiasis

Candidiasis is often referred to as a yeast infection, or thrush. It is caused by an overgrowth of Candida albicans in the body. Candida can be found on the skin, in the gastrointestinal tract, and the mouth, and when it occurs in normal amounts, it doesn’t do any harm.

However, when that aforementioned overgrowth occurs, it can cause infection and lead to conditions and symptoms such as:

  • Red, itchy skin
  • Thrush (oral candidiasis)
  • Discharge
  • Itching in the genital area (vaginal yeast infection)
  • Oesophagitis (oesophageal infection)
  • Diaper rash
  • Candida sepsis

In many cases of infection caused by the overgrowth of yeast, symptoms will be mild. The infection can cause itching, rashes and difficulty with swallowing or breathing (oesophagitis). In more severe cases, such as candida sepsis, the symptoms and repercussions of the infection can be dire. When candida gets into the bloodstream, it can cause a blood infection that may lead to fever, shock and even organ failure.

How do you treat candidiasis?

The treatment for candidiasis will vary depending on the severity of the infection and the type. In the case of a vaginal yeast infection, the most common type of candidiasis, oral antifungal medications and topical ointments can be applied to relieve symptoms and help rid the body of the overgrown yeast.

In the case of candida sepsis, treatment may need to be more extensive. Antifungal drugs will need to be administered to the patient intravenously, and the amount and type of medication will be entirely dependent on the patient’s personal medical history. Those with low white blood cells will need a specific type of antifungal to knock out the fungal overgrowth, and treatment will need to begin shortly after the onset of the infection to avoid the spread to other organs.

Medications generally used in the treatment of candidiasis include:

  • Mycostatin
  • Clotrimazole
  • Fluconazole
  • Butoconazole
  • Miconazole
  • Tioconazole
  • Voriconazole


Does Lyme disease cause candidiasis?

Although Lyme disease isn’t a direct cause of the overgrowth of candida within the body, the treatment of Lyme disease can be. Lyme disease treatment primarily involves a heavy dose of strong antibiotics. Antibiotics tend to wipe out all the bacteria within the body without prejudice, including the good bacteria. This enables yeasts to overgrow more easily. To correct the loss of the good, gut-boosting bacteria lost during treatment, Lyme patients are encouraged to undergo probiotic treatment to restore the gut flora.

In the opposite way, the overgrowth of candida albicans can actually worsen Lyme disease symptoms as well, due to its ability to increase production of cytokines. Cytokines are introduced into the body to help with immune function and cell signalling. When there are too many cytokines, however, a ‘cytokine storm’ can occur, which can lead to fever, inflammation, and occasionally very severe complications such as organ failure.


Make Well - tongue
Image by Alex Guillaume on Unsplash: Is thrush the same as candidiasis? Yes – thrush is the oral version of a candida infection.

The Candidiasis Diet

In the past, a strict no-carbohydrate diet was implemented to try and starve Candida albicans, but it has since been proven that there is no factual basis behind that specific anti-candida diet. However, there are diet changes that can be made to help battle recurring candidiasis.

Eating a diet rich in wholefoods, vitamins and minerals is a great way to avoid or help treat a candida overgrowth infection naturally. Limiting sugar intake (even consumed through fruit), introducing complex carbohydrates through wholegrain products, and increasing both fat and protein intake can also help with a candida infection. When a diet is balanced in all essential vitamins and macronutrients, the restoration of gut flora becomes easier.

Eating foods with antibiotic properties such as fresh herbs and garlic can also encourage the proper amount of candida growth within the body, and probiotics can be introduced via supplementation or through foods like kefir or yogurt. Since the overgrowth of candida bacteria is a common problem in those who suffer from Lyme disease, Make Well is also currently working on a unique formulation to help combat the problem for patients suffering from Lyme disease and its co-infections.

Featured image by qimono on Pixabay

MakeWell - Orange & Ginger Lemonade

Stimulate digestion, reduce nausea and fight the flu with vitamin-packed ginger root!! Loaded with nutrients and bioactive compounds, ginger is considered among one of the healthiest spices on the planet. With such powerful benefits for your body and brain, it's no wonder why ginger has such a long history of use in traditional and alternative medicine.


Drink in your ginger a refreshingly spiced glass of our Orange & Ginger Lemonade!

Ingredients (makes 1 Litre)

  • 4 large, sweet oranges
  • 1 small orange (decoration)
  • 1 lemon
  • 1 handful of fresh mint, roughly chopped
  • 5 cm of fresh ginger
  • 2 tablespoon honey
  • 800 ml water
  • Ice cubes


Squeeze the oranges and lemon and thinly slice the ginger. Add water, juices, ginger and honey into a saucepan and heat until the honey is fully dissolved. Transfer mixture into a jug and leave to soak overnight in the fridge. Remove the ginger with a sieve the next morning and stir through the mint.

Serve chilled in glasses with ice cubes and decorate with orange slices.

Featured image by Caglar Araz on Unsplash

Make Well - MRG plus ingredients

Many illnesses will not simply run their own course, and cannot be eliminated unless the patient has proper treatment. These illnesses can wreak havoc in the body if left for too long and generally come with a plethora of undesirable symptoms.

Often, many of these conditions can be effectively avoided with a proper diet and lifestyle. However, when it comes to getting enough of what the body needs, diet is rarely enough. Getting the right amount of essential vitamins and minerals can be difficult, especially for those living a modern lifestyle.

For patients with Morgellons disease in particular, treatment isn’t as cut and dry as eating the right foods and taking all your vitamins. Let’s learn a little more about Morgellons disease itself, and about a supplement that supports Morgellons disease treatment.

What is Morgellons disease?

Morgellons disease is a skin condition that most often presents with sores on the body that have little fibres escaping from them. The cause of the disease is still unknown, and doctors are unsure of where the infection-like illness originates.

The symptoms of Morgellons disease are:

  • Skin rashes that itch incessantly
  • A feeling of something crawling under the skin
  • String-like fibres protruding from sores
  • Depression or depressed mood
  • Fatigue
  • Short-term memory loss
  • Decline of concentration abilities

Although the disease isn’t lethal in and of itself, it can cause patients to experience a vast decrease in quality of life. Research has taken place over decades to find out what exactly causes Morgellons disease, but so far that research has come up short. However, studies have found that there could be a connection between the skin disease and borrelia, the bacteria that causes Lyme disease, or between Morgellons and other parasitic species that may be the cause of the problem.

Treatment options for Morgellons disease

Since the cause of Morgellons isn’t pinned down, treatment options can vary. Many doctors and researchers believe that Morgellons disease could be a mental illness, thus when treatment occurs, it is generally geared towards treating a possible mild case of psychosis.

Some treatment options include:

  • Cognitive behaviour therapy
  • Anti-depressant medication
  • Antipsychotics
  • Counselling and therapy

Some people with Morgellons disease have also been treated using other types of medications. Some doctors believe there is a direct link between tick-borne illnesses and Morgellons disease, so antibiotics and topical creams have also been used to soothe sores and itching.

What is the MRG Plus supplement?

The MRG Plus supplement by Make Well is a natural supplement designed to support the treatment of babesia and other parasitic infections. The supplement’s ingredients are plant-based, and it’s packed with a variety of different herbs and other natural extracts to help treat illnesses such as Morgellons disease.

Let’s take a look at the key ingredients in this supplement.


Garlic is used widely in cooking because of its unique taste, but it has also been used for centuries for its medicinal properties.

The naturopathic treatment uses for garlic include:

  • Antibacterial effect
  • Cancer inhibition
  • Cholesterol lowering
  • Hypertension prevention
  • Heart disease prevention


Make Well - garlic
Image by Steve Pb on Pixabay: Garlic has many medicinal properties, meaning it’s used in many treatment options, including a supplement that fights parasites such as MRG Plus.

Artemisia annua

Artemisia annua is a species of wormwood that was originally used in the treatment of malaria for its antibacterial properties. Artemisia annua is one of the most potent ingredients in Make Well’s MRG Plus supplement.

Ingesting artemisia annua regularly can aid in recovery from many ailments, such as:

  • Fever
  • Inflammation
  • Chronic bladder infection
  • Babesia infection


Walnut shell extract

Aside from offering up healthy fats and other nutrients such as omega-3, folic acid, vitamin B6, manganese and vitamin E, walnuts also have great antioxidant properties. The shell of the walnut, or the outer layer of skin, is mostly forgotten but offers a great therapeutic value because it contains high levels of juglones.

Juglones can act as:

  • Anti-microbials
  • Antibiotics
  • Anti-parasitic



Ginger root is often used to ease gastrointestinal discomfort. The centuries-old medicinal use of ginger has provided plenty of evidence to support its efficacy against many ailments, including nausea, colds and pain. It also has anti-inflammatory properties that can help protect against widespread inflammation.

There are various ways to ingest ginger root, such as in supplementation. Other methods for the use of medicinal ginger root include:

  • Ginger baths
  • Inhalation of ginger vapours
  • Ginger water or tea
  • Ginger wraps
  • Lozenges
  • Cooking in various dishes


Gentian and marshmallow root extract

Both gentian and marshmallow root have great medicinal properties, but gentian root is far more popular. The compounds contained in the roots of marshmallow and gentian plants can lead to lowered inflammation within the body.

They also have strong antibacterial and antiparasitic properties, which can help in the treatment of bacteria-driven infections.

Milk thistle extract

Milk thistle extract is useful in a supplement for skin irritation because it has been shown to help reduce inflammatory conditions that affect the skin. It also contains anti-ageing and antioxidant benefits, both of which can keep skin healthier longer.

In addition to its medicinal uses for skin inflammation, milk thistle extract has been shown to help stabilise cell membranes of hepatocytes. This leads to heightened liver regeneration, which is beneficial for overall health.


Make Well - milk thistle
Image by Annca on Pixabay: Milk thistle extract has been shown to help battle many types of skin inflammation, such as the specific type caused by Morgellons disease.

Thyme and fennel extract

Thyme and fennel have long been used in cooking, but studies have shown that they also possess antimicrobial and digestive health benefits as well. This is due to their high levels of vitamins and minerals the body needs for overall health.

Vitamins and minerals that can be found in thyme and fennel include:

  • Vitamin C (thyme and fennel)
  • Vitamin A (thyme)
  • Copper (thyme)
  • Fibre (thyme and fennel)
  • Iron (thyme)
  • Manganese (thyme)
  • Potassium (fennel)
  • Folate (fennel)
  • Vitamin B6 (fennel


Ysop extract

A relatively unknown medicinal plant, ysop extract is a great addition in a supplement that fights parasites because of its essential oils, flavonoids and tannins.

Flavonoids protect against toxicity by fighting off free radicals, while tannins have antimicrobial properties, which have been known to aid in recovery from parasitic infection.

The combination of different plant-based ingredients is what makes the MRG plus supplement so unique, as their properties can work simultaneously by benefiting each other. For further information on the ingredients, our list of scientific references below may be an interesting read for you!

Featured image by Kerd Kanno on Pixabay



Thakur, Ajay. "Juglone: A therapeutic phytochemical from Juglans regia L." Journal of Medicinal Plants Research 5.22 (2011): 5324-5330.

Loo, Cecilia Shi Ni, et al. "Artemisinin and its derivatives in treating protozoan infections beyond malaria." Pharmacological research 117 (2017): 192-217.

Bahmani, Mahmood, et al. "Silybum marianum: beyond hepatoprotection." Journal of evidence-based complementary & alternative medicine 20.4 (2015): 292-301.

Charles, Denys J. "Hyssop." Antioxidant Properties of Spices, Herbs and Other Sources. Springer, New York, NY, 2012. 353-356.

Dua, Anita, Gaurav Garg, and Ritu Mahajan. "Polyphenols, flavonoids and antimicrobial properties of methanolic extract of fennel (Foeniculum vulgare Miller)." European Journal of Experimental Biology 3.4 (2013): 203-208.

Forouzan, Shirin, et al. "Anti-parasitic activites of Zingiber officinale methanolic extract on Limnatis nilotica." Global Veterinaria 9.2 (2012): 144-148.

Nagai, Akiko, et al. "Growth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures. "Antimicrobial agents and chemotherapy 47.2 (2003): 800-803.

Sienkiewicz, Monika, et al. "The antimicrobial activity of thyme essential oil against multidrug resistant clinical bacterial strains." Microbial drug resistance18.2 (2012): 137-148.

Rare diseases are often hard to treat due to their limited study, and because they are often much harder to diagnose early on. Some doctors are also not well-versed in all diseases, let alone the ones that pop up in patients at a significantly low rate – so many patients suffering from a rare disease often need to see more than one specialist to get to the bottom of their symptoms.

The problem with false diagnosis is that it can lead to years of trial and error for patients, especially those who have symptoms that mimic common illnesses. In the case of an infection caused by bartonella, several different diseases can arise.

What is bartonella?

Bartonella is a type of bacteria that belongs to the family Bartonellaceae. When a person becomes infected with bartonella, it can lead to different conditions, commonly referred to as bartonellosis. These include cat scratch fever or skin striae.

Bartonella bacteria can also affect many other parts of the body, including:

  • Liver
  • Skin
  • Heart
  • Eyes
  • Blood
  • Brain

Sometimes the transmission of bartonella to a human doesn’t cause any illness at all, which makes treatment and diagnosis of disease much more difficult. People who are asymptomatic can still test positive, but require no treatment. Other levels of infection present mildly and disappear on their own.  Bartonella bacteria can often occur simultaneously with Lyme disease as a co-infection.

What is the BART Plus supplement?

When it comes to Lyme disease co-infections, treatment can be difficult. In some cases it can lead to worsened symptoms as well as longer recovery times. While both borrelia bacteria (which causes Lyme disease) and bartonella bacteria can be transmitted by ticks, the symptoms of the two can overlap tremendously, making both diagnosis and treatment harder.

Make Well’s BART Plus supplement has been created using only natural ingredients, and is designed to support Lyme patients who also have a bartonella co-infection. The supplement’s ingredients include a number of well-known herbs that have been used in relation to bartonella infections.

Let’s take a look at the ingredients in this supplement for bartonella infection.

Gou Teng

The gou teng plant has long been used as a traditional medicine, acting as a spasmolytic and easing flatulence in patients who suffer from gastrointestinal upset. It is usually taken as a powder or in tea form.

Recent studies have also shown that gou teng has the ability to modulate the immune response and can help reduce the symptoms of generalised anxiety disorder.


Make Well - lapacho tree bark
Image by Maximiliano Gomex19 on Pixabay: Lapacho tree bark is an important ingredient in a supplement that supports bartonella treatment, as it can help ease symptoms with its anti-inflammatory properties.

Lapacho Tree Bark

Originating in Brazil, the bark of the lapacho tree has been used in herbal medicine to help relieve pain. There are many other positive effects that have been reported in patients suffering from a variety of diseases.

Lapacho tree bark is often used in tea form, and can provide:

  • Lowered levels of inflammation
  • Laxative properties for those who suffer constipation
  • Antibiotic properties
  • Increased immune function
  • Decreased gastrointestinal side effects caused by medications
  • Increased red blood cell production
  • Anti-ageing properties

Some cancer patients have also benefited from the use of lapacho tree bark during chemotherapy to help reduce negative side effects.

Cistus Incanus

The reason cistus incanus was added to Make Well’s supplement for bartonella is because it has been proven to work as an antiviral and antibacterial herbal medication. There are several active ingredients and high levels of flavanols and polyphenols, both of which can have antioxidant effects.

The bioactive substances in the plant can also lead to recovery from skin diseases and immunodeficiencies. It encourages immune function by limiting the production of cytokines, which can cause inflammation throughout the body.

Other conditions that the Cistus incanus has been used include:

  • Influenza A
  • Other common colds
  • Menstrual symptoms
  • Rheumatism (conditions that affect joints, muscles, bones, cartilage)


Usnea barbata

Usnea barbata is a type of lichen that grows on branches and is used in the treatment of many conditions. The plant acts a natural version of an antibiotic and has been proven to encourage the production and formation of bacterial biofilms.

There are a number of uses for usnea barbata, including:

  • Weight loss treatment
  • Pain relief
  • Fever relief
  • Faster healing of wounds
  • Loosening of phlegm within the body
  • Sore throat and mouth treatment

In the case of Make Well’s BART Plus supplement, the antibiotic properties of the plant encourage the ridding of the bacteria from the body, which can help with faster recovery and reduction of symptoms.

Liquorice root

Liquorice root has been used for hundreds of years in Chinese medicine to help treat patients suffering from gastrointestinal issues.

The medicinal abilities of liquorice root stem from the high levels of glycyrrhizic acid found in the plant, which leads to lessened inflammation and increased immune function.

Smilax Parilla

Smilax parilla is used to supplement Lyme disease co-infection treatments due to its anti-inflammatory properties. It also has a cleansing effect throughout the body, acting as an antioxidant to remove toxins.

Due to its analgesic properties, smilax parilla can also relieve pain caused by symptoms of both Lyme disease and bartonella infection.


Make Well - garlic
Image by Joanna Kosinska on Unsplash: Garlic has been used in medicine for centuries and plays an important role in this supplement for Lyme disease co-infections.

Clove and garlic

The medicinal properties of both clove and garlic have been well-known for quite some time.

In Make Well’s BART Plus supplement, these ingredients provide patients with the extra boost they need to recover from symptoms caused by Lyme disease and bartonella infection.

Featured image by Kelly Sikkema on Unsplash



Byeon, Se Eun, et al. "In vitro and in vivo anti-inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae." Journal of ethnopharmacology 119.1 (2008): 145-152.

Fiore, Cristina, et al. "A history of the therapeutic use of liquorice in Europe." Journal of ethnopharmacology 99.3 (2005): 317-324.

Francolini, I., et al. "Usnic acid, a natural antimicrobial agent able to inhibit bacterial biofilm formation on polymer surfaces." Antimicrobial agents and chemotherapy 48.11 (2004): 4360-4365.

Hutschenreuther, A., et al. "Growth inhibiting activity of volatile oil from Cistus creticus L. against Borrelia burgdorferi ss in vitro." Die Pharmazie-An International Journal of Pharmaceutical Sciences 65.4 (2010): 290-295.

Jung, Ji Wook, et al. "Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla." Journal of ethnopharmacology 108.2 (2006): 193-197

Madamombe, I. T., and A. J. Afolayan. "Evaluation of antimicrobial activity of extracts from South African Usnea barbata." Pharmaceutical Biology 41.3 (2003): 199-202.

Sumner, Kale. "The traditional and clinical uses of sarsaparilla (Smilax species)." Australian Journal of Medical Herbalism 14.3 (2002): 114.

Zhang, Lin, et al. "Immunomodulatory activities of polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla." Carbohydrate polymers 98.2 (2013): 1458-1465.

Nowadays, it can be rare to have a healthy diet full of wholefoods and all the essential vitamins and minerals needed to sustain overall health. Between heavily processed ready-made meals to the ever-increasing availability of fast food and on-the-go options, getting everything the body needs is hard to do even in the best of circumstances. But the body still needs certain things to function at its best, and that means supplementation is often a necessary component for dietary health.

Certain multivitamins hail themselves as cure-alls, but don’t come with anywhere near enough of the essential vitamins and nutrients we need. The ingredients in a multivitamin, as well as their quantities compared to recommended daily values, are what make a supplement worth the money or not. The sheer number of options out there seems endless – but Make Well’s MITO Plus goes a step above when it comes to ingredients used.

Let’s first take a look at the best way to choose a multivitamin supplement, and then delve into a breakdown of the ingredients of Make Well’s MITO Plus.

How to choose a multivitamin

There are many factors at play when it comes to choosing the perfect multivitamin. Your age, weight, health status and sex all matter when it comes to picking the right one. For example, males and females require different daily values of certain vitamins. In particular, iron is required in higher daily amounts for woman than it is for men, because women are far more susceptible to being iron deficient.

There is also age to take into account, because certain vitamins and minerals can build up in those over a certain age, which can sometimes lead to organ damage. Also, vitamins that stay in the system of a younger person will often be depleted in someone who is on in years, making those vitamins specific to both sex and age important when choosing a multivitamin that suits you best.What’s in Make Well’s MITO plus supplement?

Make Well’s MITO Plus is a supplement that supports mitochondrial function and aids in energy metabolism. Let’s take a closer look at some of its specific ingredients.


Many essential vitamins cannot be created by the body itself, so they need to be consumed through food or supplements. Make Well’s MITO plus is full of both water-soluble and fat-soluble vitamins to help the body get what it needs, when it needs it, aiding both in overcoming chronic illness and maintaining overall optimal health throughout life.

Included in the MITO Plus supplement are:

  • Vitamin A
  • Vitamin C
  • Vitamin B1
  • Vitamin B2
  • Vitamin B5
  • Vitamin B7
  • Vitamin B9
  • Vitamin B12

These vitamins each have a specific job to do within the body, and ensuring that your body is getting enough of them all will encourage overall health.


Make Well - citrus
Image by Freestocks on Unsplash: A supplement that boosts energy will be jam-packed with vitamin C.


Minerals are needed in the body to aid in many functions, including:

  • body development
  • forming and maintaining strong bones
  • keeping nerve impulses in check.

The essential mineral included in the MITO plus supplement is magnesium. Magnesium is an important mineral with a role in over 300 functions in the body, including:

  • nerve and muscle function
  • immune system health
  • heart health
  • glucose levels
  • energy metabolism.

Some research has suggested that magnesium can help those who suffer from fatigue by reducing overall tiredness, as well as helping the mind concentrate and relax.

Other trace elements

Although trace elements don’t hold as much weight in overall health as essential vitamins and minerals do, they are an important factor in the health of the body and mind. They encourage enzyme production, pathways in the metabolic system, and the proper function of organs.

Make Well’s MITO plus contains several important elements, including:

  • Zinc
  • Copper
  • Selenium
  • Chrome
  • Molybdenum

Other ingredients

A multivitamin wouldn’t be complete without other ingredients besides vitamins, minerals and elements. The vitamins and minerals need to be packed in with something, and in the case of Make Well’s MITO Plus, those other ingredients are just as good for you as the vitamins and minerals they come with.

For example, Coenzyme Q10 is included in the multivitamin, helping the breakdown of energy and the transportation of fatty acids throughout the body. Another inclusion is ginkgo biloba, a herb that has been used as an effective assistant in overall brain health. Finally there’s quercetin, which boasts health benefits such as encouraging physical endurance.


Make Well - fruit
Image by Engin Akyurt on Unsplash: Eating a healthy diet can be difficult and often requires a supplement for energy metabolism to be complete.


Knowing exactly what you’re putting into your body when it comes to supplementation is key to ensuring that your money is going in the right place and your health is being taken care of. Choosing the right multivitamin for you is more than just picking one based on reviews from others. The path to supplementation is very personalised and needs to be approached as such.

Make Well’s MITO Plus multivitamin combines four major groups to create a supplement that can help a wide range of people, from healthy individuals who just need a little extra to those treating chronic ailments. Along with giving the body what it needs, the supplement also supports immune function, only uses natural and other plant-based ingredients, and does not contain allergens or artificial additives, making it a stand-out from many other products on the market today.

For more information on Make Well’s product range, head to our website today.

Featured image by Kayla Maurais on Unsplash

Make Well - heavy metal detoxification

Chronic Lyme disease is a complicated disorder that affects many facets of the body. Unfortunately, there is no quick treatment for the disease; successful recovery depends on a number of varying factors. Prime amongst those is the detection and accurate diagnosis of the disorder. Because chronic Lyme disease resides in a grey area of medicinal legitimacy, the misdiagnosis rates are estimated to be high. It is often confused with other chronic conditions such as MS and fibromyalgia. However, even once it is diagnosed correctly, numerous factors can hinder recovery. One of those factors is heavy metal toxicity.

Heavy metals and Lyme disease have a complicated relationship. In this article, we’ll get to the bottom of how heavy metal detoxification can aid in the treatment of Lyme patients.


Make Well - fatigue
Image by marusya21111999 on Pixabay: Lyme disease and heavy metal toxicity: the two can go hand in hand.

What is Lyme Disease?

First let’s define what we’re talking about. Lyme disease is caused by the Borrelia burgdorferi bacteria, which is passed to humans by certain species of ticks. It comes in two forms: acute and chronic. Acute Lyme involves flu-like symptoms, and onsets soon after the initial tick bite. It is easily treated with antibiotics – if it is caught in time. If it isn’t, the disease can mutate to its chronic form, which has far more severe long-term implications.

Symptoms vary wildly from patient to patient, and treatment must address both the infection symptoms and those caused by inflammation, the body’s own immune response.

What is Heavy Metal Toxicity?

Toxic heavy metals are heavy metals that become poisonous inside the body when they are not metabolised or disposed of. Over time, these metals will accumulate in the organs and tissues, causing a number of symptoms.

While there is some debate over what exactly constitutes a heavy metal, there are a number of principle elements that scientists have classified based on atomic weight. They include arsenic, copper, lead, iron, mercury and zinc. Obviously, not all of these metals are bad for you. The body requires minimal amounts of metals like iron and copper to keep healthy.

The symptoms of heavy metal toxicity can vary, but generally include fatigue, headaches, aches in your joints or muscles, altered mental health states, impaired cognitive function, and constipation.

Heavy Metals and Lyme Disease

So what exactly is the relationship between heavy metals and Lyme disease? And how might a detoxification help? Essentially, heavy metal intoxication is a major impediment to recovering from chronic Lyme disease. You might notice that many of the symptoms of heavy metal poisoning are the same as the generalised Lyme symptoms. The two sets of similar symptoms amplify each other, creating a negative feedback loop within the body. Furthermore, heavy metals can interfere with chronic Lyme treatments – for example, by interfering with antibiotic treatment.

On a deeper level, heavy metals can affect the body’s immune system. Regulation of the immune response is a critical factor in chronic Lyme treatment, and any element that hinders it can have severe repercussions. A build-up of heavy metals can, for example, interrupt enzymatic processes, thus hindering the immune system in its ability to fight off infections and resolve them naturally, or impair other biochemical reactions in the body that are enzyme-driven.


Make Well - blueberries
Image by congerdesign on Pixabay: Certain foods, like blueberries, have natural detoxification properties.

How Do You Treat Heavy Metal Toxicity?

None of this is good news, of course, especially for people already battling a chronic disease like Lyme. The answer may be a heavy metal detoxification, with the aim of eliminating these trace elements from your body. But how is this achieved?

The most effective way is through lifestyle and diet changes. The goal of the detox is to flush out the heavy metals by consuming certain ingredients and reducing or eliminating others. The results should improve your immune response, organ functions and general wellbeing, as well as making your Lyme treatment more effective.

A substance that binds to a heavy metal is called a chelator, and the process that transports the toxic waste out of the body is known as chelation. There are many ingredients that you can introduce to your diet to start this process immediately. They include leafy green vegetables, seaweed, lemon, blueberries, coconut oil or anything rich in vitamin C; these are all natural detoxifiers. Many spices are also good for heavy metal cleansing, such as ginger, basil, parsley and turmeric. Foods rich in fibre may also help to decrease heavy metal toxicity, as well as foods containing sulphur, such as garlic and broccoli, according to a relatively recent review from 2013.

If you’re worried about heavy metal poisoning, talk to your primary care provider about starting a detox as soon as possible. It’s likely you’ll notice the effects very quickly.

Featured image by yana-tik on Pixabay

Make Well - exercise

The human body was made to be in motion, which is just one reason why today's (often sedentary) lifestyles are attributed to the increase of chronic illnesses among the general population.

The risks that go along with lack of movement include obesity, weakened muscles and lowered muscle mass, cardiovascular disease, and even early mortality. While it may be hard to get enough exercise on a daily basis, it’s more important than ever to get moving as much as possible to help improve overall health and, importantly, boost immune function. Let's take a look at how exercise affects the immune system, and how you can boost yours with some fun springtime activities.

Does exercise boost immune function?

The body’s immune system is its first line of defence against illness. The system functions by determining a threat, such as a virus or bacteria, and attacking it with immune cells to eliminate it from the body. When the immune system isn’t working properly, it can make the body more susceptible to infection and can lead to chronic illness. Exercise is a great way to help boost immune function and encourage a healthy response when invaders do happen to get into the body.

Exercise can help increase immune function by improving lung function. It manages to flush out certain bacteria from the lungs and airways, which will in turn lessen the risk of catching a cold or flu. It has also been proposed that exercise has the ability to change both white blood cells and antibodies, in turn leading to a properly functioning response system.

Different types of exercise may affect the immune system in different ways. For example, cardio exercise such as running or bicycling increases heart rate and encourages faster circulation of protective cells throughout the body. Less strenuous exercise, such as yoga, helps to decrease cortisol levels in the body, improving immune function and stimulating the lymphatic system, which removes toxins from the body. Decreased cortisol can also increase circulation of oxygen to organs for healthy function.

Make Well - spring fatigue disorder
Image by Zohre Nemati on Unsplash: Spring Fatigue Disorder can affect any one and is caused by a variety of factors following the end of winter.


What is Spring Fatigue Disorder?

Spring Fatigue Disorder (SFD) is a seasonal mood/body condition. The disorder occurs when the seasons change, and it can present itself in symptoms such as chronic fatigue, depression, lethargy and anxiety. It’s thought to be caused by several different factors, including less sleep because of more daylight, physiological repairs that occur in the body caused by nutrient deficiencies left by winter, and even stress caused by the pressure to ‘enjoy’ the better weather.

Because SFD is caused by a variety of factors, there are several steps you can take to help beat the spring blues, including increasing vitamin intake, getting enough sleep and reducing overall levels of stress. Some exercises to combat spring fatigue disorder include brisk walking, outdoor hikes to help increase levels of vitamin D in the body naturally through sunlight consumption, and indoor weight training.

Immune-boosting activities for spring

When the warm weather and sunshine finally arrives, getting outside is a great way to help boost the immune system. Along with getting more sunshine and vitamin D as mentioned above, getting outside generally requires more physical activity, which boosts the immune system. Going for walks through fields of wildflowers in bloom will not only give you the boost of exercise needed to improve immune function, it will also allow you to get some rays and decrease stress because of its meditative properties.

Other outdoor activities that can help increase immune function include biking to increase cardiovascular function, taking outdoor workout classes, walking along the beach/river, and hiking through wooded areas. While outdoors in wooded areas, though, it’s important to check for ticks. Dress appropriately and take the proper steps when returning home to ensure that you have not been bitten by a possibly Lyme disease-infected tick.

Spring exercises to boost immunity during quarantine

Although the aforementioned activities may sound like a good idea, a lot of areas are currently under lockdown or quarantine because of the COVID-19 pandemic. If you are in an area where walking through a public area is not allowed, there are other things that can be done to help increase exercise, avoid SFD and increase immunity.


Make Well - yoga
Image by Kari Shea on Unsplash: During the COVID-19 lockdown, many online classes have been available at no charge so you can workout at home for free.


Following online exercise or yoga classes will help keep you busy while you’re stuck at home and will also boost immunity without much effort. Other things that can help you be active while stuck at home including walking around your neighbourhood, doing a spring deep clean of your home, or participating in exercise activities through YouTube channels or other social media networks. To keep your mind busy, picking up a new hobby could also help to boost the immune system by keeping stress levels at bay during a difficult time. Things such as crafts, online book clubs or puzzles are all activities that require focus, thus lowering cortisol levels.

Featured image by Dominik Wycislo on Unsplash

Make Well - G.I. Basic

For many people, the modern-day lifestyle involves heavy levels of processed foods, sedentary living and stress. All of these factors often contribute to gastrointestinal issues such as irritable bowel syndrome. Other causes for G.I. irritation include cancer, lactose intolerance, gallstones, ulcerative colitis, and Crohn’s disease. Patients suffering from these diseases experience an array of different uncomfortable symptoms such as stomach upset, bloating, diarrhoea, heartburn, constipation and abdominal pain.

Eating a clean diet and getting regular exercise can be helpful to some who suffer mild cases of gastrointestinal upset, but for those with specific ailments, more needs to be done to combat the debilitating symptoms. When it comes to the best supplements for managing gastrointestinal symptoms, many doctors say that probiotics are at the top of the list.

What’s is a probiotic?

Probiotics are living bacteria or yeasts that thrive in our intestinal tract. They can be found naturally in yoghurt; fermented foods such as sauerkraut, pickles and kimchi; sourdough bread; and some types of cheese. These bacteria are often hailed as ‘good’ bacteria because of the way they help with the digestive system and to keep harmful bacteria in check. The family of good and bad bacteria in the gut is called the gut microbiota, and it plays a significant role in digestion ,immune system function and overall health.

The ‘good’ bacteria in probiotics help fight off ‘bad’ bacteria as well as keeping the balance within the intestinal tract to aid metabolic function. Things such a high-processed-food diet, taking antibiotics and other medication or a high intake of residues like food chemicals and additives can throw off that balance and lead to further unwanted gastrointestinal side effects.


Make Well - probiotic
Image by Andres Siimon on Unsplash: Probiotics help to restore the healthy level of good bacteria in the gut.

How do probiotics work?

The ‘good and bad’ bacteria that live in the stomach number in the trillions. When probiotics are introduced into the gastrointestinal system, their job is to ensure there is more beneficial bacteria than ‘bad’ stuff. They do this by attaching themselves to the gut wall, taking up most of the available space and thus pushing out the bad bacteria.

The amount of living probiotics needed to combat gastrointestinal issues depends entirely on how well the body is functioning, and how many of those live bacteria are in fact doing their job. Gastrointestinal systems may be even more out of order in people who suffer from chronic illnesses, thus they will need more living cultures to help restore a healthy gut flora.

How to choose the right probiotic

Choosing the right probiotic is an important part of maintaining a healthy gut. Essentially, each person will require a different type of probiotic depending on the ailment they are suffering from, the cause of the imbalance of bacteria in the gut, and how they respond to an influx of probiotics. For example, those just in need of diet supplementation will often require a lower dose of probiotics than those suffering from chronic illness. Probiotic dose suggestions range from one billion colony-forming units to upwards of 100 billion.

Aside from the numbers, there are other things to consider when choosing the right probiotic treatment for you. There are several different strains of probiotics, all of which have different specific functions (well-known strains include Bifidobacteria and Lactobacillus). Certain bacteria can help the body break down foods such as lactose and carbohydrates, while others ensure that bad bacteria doesn’t outnumber the good. Picking the right strain for the right ailment is important in the overall fight against gastrointestinal upset.


Make Well - gut health
Image by Tumisu on Pixabay: Choosing the right probiotic is important on the road to recovery from gastrointestinal issues.

What’s a good probiotic for Lyme disease?

For those who have Lyme disease, a tick-borne infection that leads to chronic pain and illness, choosing the right probiotic can play a small role in the difference between recovering in a timely manner or having lasting effects caused by the disease.

Taking a daily probiotic can help the recovery process by rebuilding the healthy bacteria levels that are often killed off after the high course of antibiotics required to kill the Borrelia bacteria that causes Lyme disease. A live probiotic is the best bet when battling the imbalance of gut flora caused by the infection and treatment of Lyme disease.

G.I. Basic Supplement

Make Well has been creating natural supplements free from lactose, fructose and gluten that can help with chronic illness; their products have been used by professionals across the globe. Their high-dose probiotic, G.I. Basic, can help restore healthy gut bacteria by utilising 12 billion bacteria across eight strains. Along with the high levels of probiotics, the G.I. Basic supplement also includes other ingredients to aid in recovery from gastrointestinal issues, including:


The combination of pre- and probiotics used in the G.I. Basic supplement was designed to help cover the imbalance of bad bacteria on both ends. The prebiotics in the supplement work to help prep the good bacteria that are still thriving within the stomach, acting as a sort of fertiliser. The probiotics are then introduced to the most optimal area for them to attach to the gut lining and restore balance.

Vitamin B2

Riboflavin is an essential vitamin that helps the body with overall metabolic energy production. It does so by helping to maintain normal levels of mucous membranes and breaking down fats, proteins and carbohydrates. This helps keep the body’s energy levels where they need to be for proper function throughout the day.

Folic Acid

In those who suffer from a lack of red blood cells, folic acid can be used to help restore those levels as it induces cell production and cell maintenance. Also in the B vitamin family, folic acid is used in the process of DNA production and the normal function of many systems in the body, including the kidneys, eyes and cognition.

Featured image by Volodymyr Hryshchenko on Unsplash