CPN plus
to support the effective treatment of Lyme disease

Horseradish extract is used in combination with nasturtium extract as a phytotherapy for treatment of urinary tract and respiratory infections.

A randomized, double-blind, placebo-controlled trial with 174 test persons confirmed the efficacy and safety profile of nasturtium and horseradish for urinary tract infections. Another similar trial with 351 participants also confirmed that taking nasturtium and horseradish to prevent respiratory infections was equally as safe and effective. In-vitro studies show that a combination of both plant substances provides a broad antibacterial effect which covers 13 clinically relevant strains of bacteria, including MRSA and pseudomonas aeruginosa.

In addition, nasturtium extract can lead to milder symptoms in cold ailments of the respiratory tract e.g. reducing sinusitis and bronchitis. This is proven by a prospective cohort study with 858 test persons. The extract also has effects similar to those of antibiotics.

Persons suffering from acute stomach or intestinal tumors should not take this.

Scientific studies on nasturtium and horseradish as ingredients

Goos, K. H., U. Albrecht, and B. Schneider. "Efficacy and safety profile of a herbal drug containing nasturtium herb and horseradish root in acute sinusitis, acute bronchitis and acute urinary tract infection in comparison with other treatments in the daily practice/results of a prospective cohort study." Arzneimittel-Forschung 56.3 (2005): 249-257.

Goos, Karl-Heinz, Uwe Albrecht, and Berthold Schneider. "On-going investigations on efficacy and safety profile of a herbal drug containing nasturtium herb and horseradish root in acute sinusitis, acute bronchitis and acute urinary tract infection in children in comparison with other antibiotic treatments." Arzneimittel-Forschung 57.4 (2006): 238-246.

Albrecht, Uwe, Karl-Heinz Goos, and Berthold Schneider. "A randomised, double-blind, placebo-controlled trial of a herbal medicinal product containing Tropaeoli majoris herba (Nasturtium) and Armoraciae rusticanae radix (Horseradish) for the prophylactic treatment of patients with chronically recurrent lower urinary tract infections." Current medical research and opinion23.10 (2007): 2415-2422.

L-glutathione is an antioxidant comprised of the three amino acids cysteine, glutamine and glycine and which therefore belongs to the tripeptide group. Glutathione is one of the most important antioxidants and plays a significant role in the function of the respiratory organs, primarily in the lungs. The lungs are particularly sensitive to oxidative stress and have a high glutathione requirement. Scientific studies have shown how glutathione reacts to the penetration of external free radicals in the lungs, making it one of the key antioxidative protective mechanisms in the breathing apparatus.

Scientific studies on L-glutathione as an ingredient

Rahman, I., and W. MacNee. "Oxidative stress and regulation of glutathione in lung inflammation." European Respiratory Journal 16.3 (2000): 534-554. Roum, J. H., et al. "Systemic deficiency of glutathione in cystic fibrosis." Journal of Applied Physiology 75.6 (1993): 2419-2424.

Vitamin C has a wide variety of positive effects on the body. Scientific studies have proven that people who take high levels of vitamin C are much better protected against respiratory infections. Like glutathione, vitamin C is one of the most important antioxidants for cleansing and strengthening the lungs from within.

Scientific studies on vitamin C as an ingredient

Gorton, H. Clay, and Kelly Jarvis. "The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections." Journal of manipulative and physiological therapeutics 22.8 (1999): 530-533. Hunt, C., et al. "The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections." International journal for vitamin and nutrition research 64.3 (1994): 212-219.

Fennel is known for its digestive-enhancing properties but is also used to support the function of the respiratory organs. It has an anti-inflammatory effect when taken for respiratory infections and the essential oils it contains help combat bacterial and fungal infections. These have multiple uses when the upper respiratory organs, such as nose, sinuses and throat, are affected. They are able to penetrate the cell walls of harmful microorganisms and render them harmless. In addition, they have also been proven to increase the formation of secrete, which thins out the mucous in the bronchia, helping the body to release and eliminate it. This effect is boosted by an increased activity of the respiratory tissues. These tissues often feature tiny hairs which are responsible for moving mucous, dist and microorganisms out of the respiratory passages.

Scientific studies on fennel as an ingredient

Lo Cantore, Pietro, et al. "Antibacterial activity of Coriandrum sativum L. and Foeniculum vulgare Miller var. vulgare (Miller) essential oils." Journal of agricultural and food chemistry 52.26 (2004): 7862-7866. Ruberto, Giuseppe, et al. "Antioxidant and antimicrobial activity of Foeniculum vulgare and Crithmum maritimum essential oils." Planta medica 66.08 (2000): 687-693. Dua, Anita, Gaurav Garg, and Ritu Mahajan. "Polyphenols, flavonoids and antimicrobial properties of methanolic extract of fennel (Foeniculum vulgare Miller)." European Journal of Experimental Biology 3.4 (2013): 203-208. Roby, Mohamed Hussein Hamdy, et al. "Antioxidant and antimicrobial activities of essential oil and extracts of fennel (Foeniculum vulgare L.) and chamomile (Matricaria chamomilla L.)." Industrial crops and products 44 (2013): 437-445.

As with fennel, aniseed is known for encouraging the digestion and for its positive effect on the respiratory organs. The University of Wurzburg found that the key substance, which is also responsible for these effects in fennel seed, is the essential oil anethole. This oil has an expectorant and antispasmodic effect by increasing the secretion of bronchial mucous in the lungs and by activating the tiny hairs which eliminate the mucous in the bronchia. Furthermore, an impressive bacteriostatic effect was also observed.

Scientific studies on aniseed as an ingredient

Gülçın, İlhami, et al. "Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts." Food chemistry 83.3 (2003): 371-382. Al-Bayati, Firas A. "Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts." Journal of ethnopharmacology 116.3 (2008): 403-406.

As in the case of aniseed and fennel, thyme also contains a high level of essential oils which can have antibacterial, anti-inflammatory, expectorant and antispasmodic effects. Thyme is therefore frequently used for coughs, colds, sore throat and hoarseness. It is commonly known as a natural antibiotic and is often a popular choice for respiratory infections caused by bacteria. At the same time, the essential oils stimulate the activity of the cilia hairs on the mucous membranes of the respiratory passages. They help to thin out any thick mucus so that it can be eliminated or coughed up more easily.

Scientific studies on thyme as an ingredient

Al-Bayati, Firas A. "Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts." Journal of ethnopharmacology 116.3 (2008): 403-406. Engelbertz, Jonas, et al. "Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect." Journal of ethnopharmacology 141.3 (2012): 848-853. Sienkiewicz, Monika, et al. "The antimicrobial activity of thyme essential oil against multidrug resistant clinical bacterial strains." Microbial drug resistance18.2 (2012): 137-148. Sienkiewicz, Monika, et al. "Antibacterial activity of thyme and lavender essential oils." Medicinal Chemistry 7.6 (2011): 674-689.

Zinc and selenium belong to the trace elements which are only present in our bodies and our diet in very small amounts. Zinc supports the normal function of the immune system and can protect parts of our cells from oxidative stress. Scientific studies have repeatedly proven how this trace element can prevent colds or reduce the severity of their symptoms. Selenium is also important for healthy lung function. Studies have shown that patients with chronic-obstructive lung disease had significantly lower levels of selenium in their plasma than healthy control persons.

Scientific studies on zinc and selenium as ingredients

Sazawal, Sunil, et al. "Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial." Pediatrics 102.1 (1998): 1-5. Hulisz, Darrell. "Efficacy of zinc against common cold viruses: an overview." Journal of the American Pharmacists Association 44.5 (2004): 594-603. Santos, M. C., et al. "Systemic markers of the redox balance in chronic obstructive pulmonary disease." Biomarkers 9.6 (2004): 461-469.