TBB plus
to support treatment of Lyme disease

TBB-Plus

Natural nutritional supplement for supportive treatment of Lyme disease

TBB plus is a natural nutritional supplement rich in functional ingredients carefully selected on the basis of numerous scientific studies to support treatment of Lyme disease.

TBB plus, our nutritional supplement for supportive treatment of Lyme disease, contains artemisia annua, andrographis paniculata, polyporus umbellatus, grape seed, grapefruit seed and garlic.

Ingredients

Artemisia annua
This annual plant, also known as sweet wormwood, was originally used to treat malaria. Since both malaria and babesiosis are caused by so-called protozoa, it is generally accepted that artemisia could also be helpful in treating an infection with babesia (one of the most common co-infections of Lyme disease).

Scientific studies

Mueller, Markus S., et al. "Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria." Transactions of the Royal Society of Tropical Medicine and Hygiene 98.5 (2004): 318-321.
Ferreira, Jorge FS, et al. "Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer." Molecules 15.5 (2010): 3135-3170.
Nagai, Akiko, et al. "Growth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures. "Antimicrobial agents and chemotherapy 47.2 (2003): 800-803.
Elfawal, Mostafa A. "Dried whole plant Artemisia annua as a novel antimalarial therapy." (2014)
Andrographis paniculata
The andrographis paniculata plant, also known as kalmegh or "Indian echinicea" was first used in ayurvedic medicine. It has been traditionally accepted that it has an anti-inflammatory and immune-modulating effect. A wide range of scientific studies have also examined its potential use in diseases such as malaria, cancer or Lyme disease.

Scientific studies

Sheeja, K., P. K. Shihab, and G. Kuttan. "Antioxidant and anti-inflammatory activities of the plant Andrographis paniculata Nees." Immunopharmacology and Immunotoxicology 28.1 (2006): 129-140. Poolsup, N., et al. "Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials." Journal of clinical pharmacy and therapeutics29.1 (2004): 37-45.
Rajagopal, Sriram, et al. "Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata." Journal of experimental therapeutics and oncology 3.3 (2003): 147-158.
Dua, V. K., et al. "Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata." Journal of ethnopharmacology 95.2 (2004): 247-251.
Mishra, Kirti, et al. "Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin." Malaria Journal 8.1 (2009): 26.
Kumar, R. Ajaya, et al. "Anticancer and immunostimulatory compounds from Andrographis paniculata." Journal of ethnopharmacology 92.2 (2004): 291-295.
Puri, Anju, et al. "Immunostimulant agents from Andrographis paniculata."Journal of Natural products 56.7 (1993): 995-999.
Suvarna, Reshma. "Clinical Roundup: Selected Treatment Options for Lyme Disease." Alternative and Complementary Therapies 18.4 (2012): 220-225.
Hyman, From Dr. "Lyme Disease and Andrographis."
Alexander, Walter. "2012 Integrative Healthcare Symposium: Treating the Pain of Lyme Disease and Adopting Lifestyle Change as Therapy." Pharmacy and Therapeutics 37.4 (2012): 247.
Polyporus umbellatus
Also known as "lumpy bracket" or "umbrella polypore", the polyporus umbellatus fungi has a long history in traditional Chinese medicine (TCM), where it is treasured as the oldest natural antibiotic in the world. It contains so-called polysaccharide and polypeptide, which many scientific studies have proven to have an immune-modulating and anti-tumor effect.

Scientific studies

大澤孝臣, et al. "Studies on constituents of fruit body of Polyporus umbellatus and their cytotoxic activity." Chemical and pharmaceutical bulletin 40.1 (1992): 143-147.
Li, Xingqun, and Wen Xu. "TLR4-mediated activation of macrophages by the polysaccharide fraction from Polyporus umbellatus (pers.) Fries." Journal of ethnopharmacology 135.1 (2011): 1-6.
Zhao, Ying-Yong. "Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: A review." Journal of ethnopharmacology 149.1 (2013): 35-48.
Shi, J. J., F. Miao, and F. L. Liu. "Therapeutic effect of medicinal herbs and western drugs on hepatitis B virus." World J Gastroenterol 4. Suppl 2 (1998): 61-62.
Sun, Ye, and Xiaoyan Zhou. "Purification, initial characterization and immune activities of polysaccharides from the fungus, Polyporus umbellatus." Food Science and Human Wellness 3.2 (2014): 73-78.
Grape seed
Grape seeds contain a high polyphenol content and also OPC (oligomeric proanthocyanidins). Over recent years, grape seed extract and primarily the OPC in it has gained popularity as a secret anti-aging weapon. Numerous books have now been published on the subject. However, the extract is mainly known for its anti-oxidative and anti-inflammatory effects. Due to its potential proactive influence at a cellular level, OPC is now being discussed in connection with cancer research.

Scientific studies

Bagchi, Debasis, et al. "Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention." Toxicology 148.2 (2000): 187-197.
Jayaprakasha, G. K., Tamil Selvi, and K. K. Sakariah. "Antibacterial and antioxidant activities of grape (Vitis vinifera) seed extracts." Food research international 36.2 (2003): 117-122.
Al-Habib, Aamar, et al. "Bactericidal effect of grape seed extract on methicillin-resistant Staphylococcus aureus (MRSA)." The Journal of toxicological sciences 35.3 (2010): 357-364.
Baydar, Nilgün Göktürk, Gülcan Özkan, and Osman Sağdiç. "Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts." Food Control 15.5 (2004): 335-339.
Jayaprakasha, G. K., R. P. Singh, and K. K. Sakariah. "Antioxidant activity of grape seed (Vitis vinifera) extracts on peroxidation models in vitro." Food chemistry 73.3 (2001): 285-290.
Grapefruit seed
Grapefruit seed extract is primarily known for its specific secondary plant substances and has for many years been a valuable secret weapon against bacteria, fungi and viruses. Many studies already show that grapefruit extract develops an anti-bacterial effect in a dilution of 1:1000. Grapefruit seed extract is also a useful supportive measure in the treatment of Lyme disease. An in-vitro trial shows the positive effect of the extract particularly on the so-called cystic forms of the borrelia bacteria, against which antibiotics have little or no chance.

Scientific studies

Reagor, Lee, et al. "The effectiveness of processed grapefruit-seed extract as an antibacterial agent: I. An in vitro agar assay." The Journal of Alternative & Complementary Medicine 8.3 (2002): 325-332.
Heggers, John P., et al. "The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity." The Journal of Alternative & Complementary Medicine 8.3 (2002): 333-340.
Brorson, Ø., and S-H. Brorson. "Grapefruit seed extract is a powerful in vitro agent against motile and cystic forms of Borrelia burgdorferi sensu lato."Infection 35.3 (2007): 206-208.
Cvetnic, Z. D. E. N. K. A., and S. A. N. D. A. Vladimir-Knezevic. "Antimicrobial activity of grapefruit seed and pulp ethanolic extract." Acta Pharm 54.3 (2004): 243-250.
Pistelli, Luisa, and Irene Giorgi. "Antimicrobial properties of flavonoids." Dietary phytochemicals and microbes. Springer Netherlands, 2012. 33-91.
Garlic
Most of us are aware that garlic is not only used in the kitchen but also has a valued medicinal use. Many scientific studies now confirm the efficacy of this ingredient in its traditional usage in natural medicine. The key ingredient in garlic, responsible also for its characteristic odor, is the sulfur compound allicin. In addition to its antibacterial effect, primarily in the digestive system, recent studies have concentrated on and also confirmed its cancer-inhibiting properties.

Scientific studies

Duke, J. "Herbs with anti-Lyme potential." TOWNSEND LETTER FOR DOCTORS AND PATIENTS 285 (2007): 114.
Curtis, Hannah, et al. "Broad-spectrum activity of the volatile phytoanticipin allicin in extracts of garlic (Allium sativum L.) against plant pathogenic bacteria, fungi and Oomycetes." Physiological and Molecular Plant Pathology 65.2 (2004): 79-89.
Iwalokun, B. A., et al. "In vitro antimicrobial properties of aqueous garlic extract against multidrug-resistant bacteria and Candida species from Nigeria." Journal of medicinal food 7.3 (2004): 327-333.
Ankri, Serge, and David Mirelman. "Antimicrobial properties of allicin from garlic." Microbes and infection 1.2 (1999): 125-129.
Al‐Delaimy, K. S., and S. H. Ali. "Antibacterial action of vegetable extracts on the growth of pathogenic bacteria." Journal of the Science of Food and Agriculture 21.2 (1970): 110-112.
Rees, L. P., et al. "A quantitative assessment of the antimicrobial activity of garlic (Allium sativum)." World Journal of Microbiology and Biotechnology 9.3 (1993): 303-307.

Plants which influence our health and well-being can also have side effects. This page is designed to provide general information about these plants but is not intended as a guide for self-medication.

Study

University Jyväskylä Finnland (the whole study)

TBB PLUS Studie
TBB Plus Studie with background subtracted